Our Evidence Base

MedScience Research Group along with its divisions AllergiEnd and AllergiEnd aim to enhance our clients’ quality of life through research, evidence-based diagnostics, innovative intervention, education, promotion and distribution, while also enhancing the physician’s medical practice. Our diagnostic systems and allergen immunotherapy methods are known for achieving meaningful, long-term allergy and asthma improvements throughout the population we serve.

Evidence-based medicine (EBM) is the conscientious, explicit and judicious use of current best evidence in making decisions about health strategies to promote the health of individuals, communities, and populations. The practice of EBM means integrating local expertise with the best available external evidence yielded by systematic research. EBM requires conducting cross-disciplinary literature searches, applying rules of evidence and appraisal of study quality, and selecting the most effective programs.

EBM asks the practitioner to present to the patient consumer a reliable summary of the treatment area of interest, including its strengths, weaknesses, and recommendations. In practice, clinicians contextualize the best available research evidence by integrating it with their individual clinical expertise and their patients’ values and expectations. The incorporation of patient values and clinical expertise in EBM partly recognizes the fact that many aspects of health care depend on individual factors. These include variations in individual physiology and pathology as well as quality-of-life and value-of-life judgments.

These factors are only partially subjected to scientific inquiry and sometimes cannot be assessed in controlled experimental settings. Application of available evidence is therefore dependent on patient circumstances and preferences and remains subject to input from personal, political, philosophical, religious, ethical, economic, and aesthetic values leading to more evidence-based healthcare as a whole.

EBM has evolved from the critical need to bridge the gap between research and practice. EBM applies research information (evidence) to clinical practice, emphasizing the importance of the use of quantitative (as well as qualitative) evidence in the art of clinical decision making. It aims to make decision making more structured and objective by better reflecting the evidence from research. By introducing the use of research information in clinical decision making, particularly from clinical epidemiology, EBM has driven a transformation of clinical practice and medical education.

In a 1996 article for the British Medical Journal, authors from the U.S., Canada and U.K. discussed the origins, definition and practical implications of evidence-based medicine and how its usage equips clinicians to make the best decisions in terms of individual patient care. By integrating individual clinical expertise with the best available clinical evidence derived from systematic research, the authors suggest that patient-centered, compassionate care can be achieved. (Sackett D, Rosenberg W, Gray J, Haynes, B, Richardson W. Evidence-based medicine: What it is and what it isn’t. BMJ. 1996; 312: 71-72.)

The best physicians utilize both evidence and clinical expertise to maximize best-practice techniques. The evolution of this technique in terms of medical education programs results in physicians becoming even more successful in the treatment of their patients.

References and sources for our approaches by category

This compilation of allergy and immunotherapy references and summaries are included for your reference, however this list can never be considered exhaustive due to the nature of science. This research informs our diagnostic system and immunotherapy method design with the best possible evidence for effectiveness.

We examine a broad body of evidence and continue to weigh the subjective hypothesis-based approaches with empirically-tested research findings. Whenever possible, we’ve included the author, title and publication so that you may easily search and read these articles in their entirety. As always, we’re open to discussion, and we encourage your questions and comments through our various forums.

Allergies and Asthma

https://www.aaapc.org/i4a/pages/index.cfm?pageID=3326 accessed online November 11 2016.

https://www.aafa.org/page/allergy-facts.aspx  accessed online November 11 2016.

American College of Allergy, Asthma and Immunology — Graduate Medical Education and Workforce Issues in Allergy and Immunology 2008.

American College of Allergy, Asthma, and Immunology. Allergy Facts. https://acaai.org/news/facts-statistics/allergies (Retrieved April 8 2015)

https://www.marketsandmarkets.com/Market-Reports/allergy-diagnostics-market-232871701.html accessed online November 11 2016.

D’Amato et al. Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization. World Allergy Organization Journal (2015) 8:25

Fighting allergies beyond symptoms: The European Declaration on Immunotherapy. Eur. J. Immunol. 2011. 41: 2802–2804.

Haahtela T, Holgate S, Pawankar R, et al. The biodiversity hypothesis and allergic disease: World Allergy Organization position statement. World Allergy Organization Journal. 2013;6:3

Johansson SGO, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF, Motala C, Ortega Martell JA, Platts-Mills TAE, Ring J, Thien F, Van Cauwenberge P, Williams HC. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol 2004; 113: 832-836.

Kaiser HB. Risk factors in allergy/asthma. Allergy Asthma Proc. 2004; 25:7-10

Meltzer EO, Blaiss MS, Derebery MJ, et al. Burden of allergic rhinitis: results from the Pediatric Allergies in America survey. J Allergy Clin Immunol. 2009;124(Suppl 1):S43-70.

Ober C, Tao T. The genetics of asthma and allergic disease: A 21st century perspective. Immunol Rev. 2011; 242:10–30.

Okada, H. Kuhn, C. Feillet, H. and Bach, J. The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update. British Society for Immunology, Clinical and Experimental Immunology, 160: 1–9. 2010.

Pawankar. Allergic Disease and Asthma: a global public health concern and a call to action. World Allergy Organization Journal 2014, 7:12

Pawankar et al. The WAO White Book on Allergy (Update 2013).

Pullen F. YouTube Interview accessed November, 15 2016 at https://www.youtube.com/watch?v=egrWycQ3zvI

Reid, C. et al. Aeroallergens, Allergic Disease, and Climate Change: Impacts and Adaptation. EcoHealth 6, 458–470, 2009

Salo PM, Calatroni A, Gergen PJ, et al. Allergy- related outcomes in relation to serum IgE:results from the National Health and Nutrition Examination Survey 2005-2006. J Allergy Clin Immunol. 2011; 127(5):1226-1235, e7.

Slavin, R. Reisman, R. Expert Guide to Allergy and Immunology. American College of Physicians; 1st edition April 15, 1999.

Strachan, D. Hay fever, hygiene, and household size. Br Med j 1989;299:1259-60.

Wolf et al. Elevated atmospheric CO2 concentrations amplify Alternaria alternate sporulation and the total antigen production. Environ Health Perspectives 2010, 118:1223-1228

Skin Testing

Bagg et al. Systemic reactions to percutaneous and intradermal skin tests World Allergy Organisation Journal 2007

Allergen Immunotherapy

Canonica et al. Sublingual Immunotherapy: World Allergy Organization Position Paper 2013 Update. World Allergy Organization Journal 2014, 7:6

Cox et al. Allergen Immunotherapy: A practice parameter third update. J Allergy Clin Immunol. January 2011.

Lifestyle Medicine

Azad, M et al., “Gut Microbiota of Healthy Canadian Infants: Profiles by Mode of Delivery and Infant Diet at 4 months,” CMAJ 185, no 5 (March 19, 2013):385-94

Chronic Conditions: A Challenge for the 21st Century,” National Academy on an Aging Society 2000

Devereux G. et al. Editorial. Vitamin D and Asthma Time for Intervention? .Am J Respir Crit Care Med Vol 179. pp 739–742, 2009

Fernández-Sánchez , Madrigal-Santillán  E, Bautista M, et al. Inflammation, oxidative stress, and obesity. Int. J. Mol. Sci. 2011, 12, 3117-32

Grey et al. Cumulative Use of Strong Anticholinergic Medications and Incident Dementia. .JAMA Intern Med. 2015 March 1; 175(3): 401–407. doi:10.1001/jamainternmed.2014.7663

Kemp et al. Epinephrine: The Drug of Choice for Anaphylaxis. Statement of the World Allergy Organization. World Allergy Journal, July 2008.

Litonjua AA, Weiss ST. Is Vitamin D Deficiency to Blame for the Asthma Epidemic? J Allergy Clin Immunol. 2007; 120:1031-5

MedScape Business of Medicine. 9 Ancillary Services That Can Boost Practice Revenue. Accessed online November, 15 2016.

https://www.medscape.com/viewarticle/828246 WebMD, LLC 2014.

McLellan, L. Sheeto, M. Grogan, T. A Guide to Environmental Allergens. A MedScience Research Group Publication (Florida 2016).

Modh D, Katarkar A, Thakkar B, Jain A, Shah P, Joshi K. Role of vitamin D supplementation in allergic rhinitis. Indian J Allergy Asthma Immunol 2014;28:35-9.

Moreira et al. A World Allergy Organization international survey on physical activity as a treatment option for asthma and allergies. World Allergy Organization Journal 2014 7:34.

Pearlmutter, D. Brainmaker. Little Brown and Company (New York 2015).

Phelps, K. Allergies, part of General Practice: The Integrative Approach series. Elsevier Australia 2011.

Poon AH, Laprise C, Lemire M, et al. Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy. Am J Resp Crit Care Med. 2004; 170:967-73

Taback SP, Simons ER. Anaphylaxis and vitamin D: A role for the sunshine hormone? J Allergy Clin Immunol.  2007;120:128-130

Weiss S. Bacterial Components plus vitamin D: The ultimate solution to the Asthma (autoimmune disease) Epidemic? .J Allergy Clin Immunol . 2011 May ; 127(5): 1128–1130